Support for Microsoft Office 2000 finally ended yesterday. For many, this doesn't mean much because most people have upgraded to Office 2003 or 2007.
If you haven't yet made the jump to 2007 and you're waiting for the new Office 2010, you can get a peek of what to expect with the launch of the Microsoft Office 2010 Technical Preview. You'll find tons of video of your favorite application.
My suggestion is you don't jump straight from Office 2003 to 2010 as you'll find the learning curve much greater than if you move to Office 2007 first. Office 2010 has a lot of familiar features of 2007, but enhanced. I'm personally impressed with the new slide transitions in PowerPoint as well as the photo and video editing inside the program. If you are currently using Office 2007, you'll find the transition to Office 2010 much easier.
I could go into detail about some of the exciting things coming, but you really should just watch the videos for yourself. You just have to see it to get the full effect.